Proteasome inhibitors are a group of drugs that are mostly used in treatment of multiple myeloma. I think that brings an interesting concept to the field of cardio-oncology where we tend to focus a lot on the diagnosis of cardiotoxicity.

It’s important to mention that multiple myeloma patients tend to be patients with a lot of pre-existing cardiovascular risk factors. Today, screening for cardiovascular function or cardiac function informs whether doing an echocardiogram to assess left ventricular ejection fraction is or is not indicated for those receiving either bortezomib or carfilzomib, which are the two most commonly used proteasome inhibitors.