Amiloride, An Old Diuretic Drug, Is a Potential Therapeutic Agent for Multiple Myeloma


The search for new drugs that control the continuous relapses of multiple myeloma is still required. Here, we report for the first time the potent antimyeloma activity of amiloride, an old potassium-sparing diuretic approved for the treatment of hypertension and edema due to heart failure.

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Sleep Apnea Drives Multiple Myeloma in Aggressive Way, Mice Study Finds


Is Sleep Apnea a way to a cure or treatment for MM?

“Sleep apnea can drive the development of aggressive multiple myeloma in mice resistant to the cancer, a study found, suggesting that the sleep disorder is a modifiable risk factor for this disease.”

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Hello 58…I’m Still Here

As another year comes and goes, having a diagnosis of Smoldering Multiple Myeloma makes it a bit challenging as you don’t know whether to be happy that you are a year older or that your cancer has not started acting up.

Wow, that is a depressing sentence.

To be true, after almost three years since my doctor told me what was up, I have settled into the routine of “life as normal” since my cancer has remained in the same state… active but not aggressive.

I can say that I don’t think about it day in and day out unless I read something about Myeloma or my three month blood work notice comes up in iCal.  I have learned to live with it and am not letting it dominate my thought process.

That’s not to say that sometimes I get hit with a wave of “Oh my God, I have cancer”, cuz I do, but not very often.

At the end of the day, I know what I have so that is power, I have support of doctors and family who are cheering me on every day, and I have done all that I can do to be a healthy person with or without cancer.  Really, that is all any of us can do.

So, there it is.  Another year living with a cancer diagnosis.  Another year of maybe this year, but also another year of live as normal or as normal as can be.  That is pretty good and if 59 comes the same way, I will consider that a win and just copy and paste this post then.

Hugs to all,


Proteasome Inhibitors for Multiple Myeloma Treatment

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Proteasome inhibitors are a group of drugs that are mostly used in treatment of multiple myeloma. I think that brings an interesting concept to the field of cardio-oncology where we tend to focus a lot on the diagnosis of cardiotoxicity.

It’s important to mention that multiple myeloma patients tend to be patients with a lot of pre-existing cardiovascular risk factors. Today, screening for cardiovascular function or cardiac function informs whether doing an echocardiogram to assess left ventricular ejection fraction is or is not indicated for those receiving either bortezomib or carfilzomib, which are the two most commonly used proteasome inhibitors.

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